Revolutionizing Crystallization with Secoya Technology
Precise Control, Enhanced Efficiency, Superior Results
ADS Processus Pharmatech, a pioneer in pharmaceutical technology, is excited to partner with Secoya to bring you the future of crystallization. The Secoya Crystallization Technology (SCT) is a game-changer, offering unparalleled control over the nucleation process. By precisely manipulating nucleation rates, SCT ensures consistent and efficient crystallization, leading to higher product yields and superior quality.
Secoya Crystallization Technology (SCT):
The SCT is a revolutionary technology that optimizes the nucleation process of molecules in solution. By precisely controlling nucleation rates within specific timeframes, SCT ensures:
- Consistent Crystallization: Reliable and predictable outcomes across various molecules.
- Enhanced Efficiency: Increased product yields and reduced production time.
- Superior Quality: Improved purity and particle size distribution.
SCT Product Range:
- SCT-Lab 2.0: A compact and versatile solution for laboratory-scale research and development.
- SCT-PILOT: A scalable pilot-scale system for process optimization and validation.
- SCT-ICE Crystallization Unit: An industrial-scale solution for high-volume production.
By leveraging the power of SCT, ADS Processus Pharmatech and Secoya are empowering the pharmaceutical industry to achieve new heights in crystallization efficiency and product quality.
Secoya's SCT - LAB 2.0
The Secoya Crystallization Technology SCT-LAB instrument streamlines the crystallization process with its integrated stock solution heating and agitation, eliminating the need for external handling. The redesigned mixing inserts and reactor holders enable faster and easier exchange without compromising watertightness, thanks to a screw-free design. The instrument’s enhanced thermal stability ensures efficient and uniform heating and cooling throughout the system, including the tubing connecting syringes and inserts. The dedicated Huber Kaltemaschinebau thermostat, controlled by compliant software, further optimizes temperature control. These features collectively contribute to a more efficient and reliable crystallization workflow.
- Temperature antisolvent from 5 to 85 °C (antisolvent precooled in fridge)
- Temperature solution from 25 to 85 °C
- Temperature reactor from 0 to 75 °C, agitated
- Volume stock solution 100 mL, agitated and heated in place
- Volume stock antisolvent 250 mL, agitated and heated in place
- Volume solution per test from 1 to 20 mL, syringes are preheated and precooled
- VFlow rate solution and antisolvent from 1 to 50 mL/min
- 6 mixing inserts for cooling and antisolvent crystallization
- 7 different reactors for cooling and antisolvent crystallization
- Unit dimensions 45 x 45 x 45 cm (L x W x H)
- Weight 28 kg
- Stand-Alone Instrument With A Small Footprint : Maximize your laboratory efficiency with this compact device (45 x 45 x 45cm), designed to operate at full capacity without the need for additional instrumentation or a computer.
- Precise Temperature Control Optimazing Nucleation: SCT-LAB 2.0 is equipped with a heating element reaching up to 85°C for the solution, whereas the antisolvent syringe can be heated to the same temperature or even cooled down to 5°C.
- Multiple Mixer Inserts Enhancing Versatility : Whether you want to perform cooling crystallization or antisolvent crystallization, the instrument seamlessly integrates several microfluidic mixers which are
positioned right before the entry of the reactor. - Ingenious Conception Coupled With An Intuitive Software : Performing a test is as easy as simply introducing the desired temperatures, flow rates and volumes and let the instrument reach and stabilize at these temperatures. Then, the tests follow very rapidly with the intuitive software.
Secoya's SCT - PILOT
The SCT-PILOT is a versatile crystallization unit that bridges the gap between lab-scale and industrial production. By replicating the conditions of the SCT-LAB unit on a larger scale, it enables seamless upscaling studies, ensuring consistent results across different scales. Its compatibility with cGMP software and customizable vessel volumes make it suitable for both research and clinical batch production. The SCT-PILOT offers a high degree of flexibility and control over the crystallization process, allowing for the optimization of various parameters such as temperature, pressure, and agitation rate. Additionally, its modular design and ease of integration with different slurry treatment systems make it a valuable tool for a wide range of crystallization applications.
- Dimensions: 120 x 60 x 180 LxWxH, on wheels
- Identical Reactor setup of laboratory instrument rajouter dimension
- Fluidic setup of industrial equipment
- Antisolvent and cooling crystallization
- Broad temperature limits
- Fully automated unit
- In-depth testing continuous operation and erronous operation control
- Recipe determination
- GLP and cGMP versions available
Secoya's SCT - ICE CRYSTALLIZATION UNIT
The cGMP SCT-ICE unit offers a flexible and customizable solution for various crystallization processes. Its modular design allows for easy adaptation to different production needs, ensuring efficient and versatile operation. By adhering to ICH Q13 guidelines, the unit prioritizes quality and regulatory compliance. The integration of open communication software facilitates seamless integration into Industry 4.0 environments, enabling advanced process monitoring and control. With its adaptability to different crystallization techniques and customization options, the SCT-ICE unit provides a reliable and efficient solution for the pharmaceutical industry.
- 5 and 10 module versions, based on Secoya Crystallization Technology
- Operation freely selectable between 1 and 5 (10) modules: 4 to 20 (40) kg/day of crystalline product*
- Change between cooling and antisolvent mode by using different modules
- Modules may be standard reactors or molecule specific
- Manual, visual and software control of coupling modules
- Two buffer tanks inside, feeding from outside with volume control (accessible with doors and frame panels), volumes may be adjusted according to client
- 1 plug, 1 ethernet cable for data transport
- Unit dimensions: 2.5 x 1 x 1.80 m³ (LxWxH)
- Easy coupling with retention tanks or filtration unit (contact us for your isolation preference)
- All materials, assembly and software are GMP compliant
*Calculation made using 100 mg/mL solid yield and flow-rate of 30 mL/min per module
Applications Of SECOYA's Products
- Lipid nanoparticles – LNP technology has emerged as the leading encapsulation method for complex APIs, including mRNA-based products
- Liposomes
- Polymeric Micelles
- Lipid-Polymer Conjugate Systems
- Suspensions
- Emulsions
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