DIANT®’s LARU & LiFT : Experience The Future Of Nanoparticle Technology
Powered by DIANT® Jet Technology, Laru & Lift offers unparalleled precision and efficiency in nanoparticle production
The pharmaceutical industry is on the brink of a transformative era, driven by the groundbreaking advancements in nanoparticle technology. DIANT®, a visionary leader in this field, has developed the revolutionary DIANT® Jet technology, a game-changer that is redefining the landscape of nanoparticle manufacturing.
Why DIANT® Jet Technology?
- Continuous Processing: Unlike traditional batch processes, DIANT® Jet technology enables continuous production, significantly enhancing efficiency and reducing costs.
- Uniform Particle Size: The precise control offered by DIANT® Jet technology ensures consistent particle size distribution, leading to improved product quality and performance.
- Advanced Control: DIANT®’s advanced control systems provide unparalleled precision over critical parameters, optimizing the manufacturing process.
- Scalability: The technology seamlessly scales from R&D to commercial production, accommodating diverse needs and volumes.
Our Partnership with DIANT®
As an authorized distributor of DIANT® products, we are proud to offer following cutting-edge solutions that empower the pharmaceutical industry
DIANT® LARU Discovery : Your Key to Efficient LNP Processing
DIANT®’s benchtop The DIANT® LARU Discovery is a cutting-edge, low-flow, low-dead-volume system designed for nanoparticle research. Its patented turbulent jet technology enables ultra-low volume test runs, ideal for multi-mode specification and optimization of nanoparticle processing. This innovative system is designed to streamline research workflows and accelerate the development of nanoparticle-based therapies. By minimizing material consumption and maximizing efficiency, the LARU Discovery empowers researchers to explore a wider range of formulations and process parameters. With its scalability and seamless integration with DIANT® systems across various scales, the LARU Discovery bridges the gap between research and commercial production, facilitating a seamless transition from benchtop to large-scale manufacturing.
- Minimum Collection Volume: 2-3 mL (per run)
- Solvent Flow Rate: 20 mL/min (nominal)
- Flow Rate Ratio: 2-8
- E1/A1 Pump Type: Syringe
- Dilution Pump Type: Peristaltic (enables 0-350 mL/min dilution rates)
- Operating Temperature Range: 15-30 degrees C
- Power Requirements: 110/220 VAC, 200 W max.
- With other DIANT solutions, scalable from R&D to commercial cGMP manufacturing
- Enables a direct translation to continuous nanoparticle processing
- Produces nanoparticles of various sizes: ~25 d.nm to >500 d.nm
- Collects volumes as low as 2 mL (per run)
- Has standard connections for bottles, tubes, or 2D bags for ease of use
DIANT® LARU: Your Laboratory-Scale Nanoparticle Powerhouse
DIANT®’s benchtop LARU is a versatile laboratory nanoparticle synthesis system designed to bridge the gap between R&D and commercial-scale production. This compact yet powerful system enables researchers to explore and optimize nanoparticle formulations, including lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions. With its continuous processing capabilities, the LARU offers superior efficacy and encapsulation compared to traditional batch methods. Its scalable design ensures seamless transition to larger-scale DIANT® LiFT systems, making it an ideal solution for academic institutions, research laboratories, and pharmaceutical companies.
- Dimensions: 30 x 30 x 12 in. (76 x 76 x 30 cm)
- Maximum output flow rate: 400 mL/min
- Solvent flow rate: 20 mL/min
- Flow rate ratio: 2-8
- Dilution port
- Touch-screen HMI
- Data logging
- Voltage & frequency: 100-240 V & 50/60 Hz
- Continuous and Batch Processing: Offers flexibility for various research needs.
- Scalable Nanoparticle Production: Produces nanoparticles ranging from ~25 d.nm to >500 d.nm.
- Inline Processing Capabilities: Enables inline dilution, drug loading, and nanoparticle modification for enhanced efficacy and encapsulation.
- Pilot-Scale Production: Produces lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions.
- Minimal Volume Requirements: Collects volumes as low as 20 mL for efficient short runs.
- User-Friendly Design: Features standard connections for bottles, tubes, and 2D bags for easy operation.
DIANT® LiFT : Revolutionize Your Nanoparticle Production
The DIANT® LiFT is a versatile and scalable commercial lipid nanoparticle production system that seamlessly transitions from benchtop to large-scale manufacturing. It enables the continuous production of high-quality, liquid-injectable nanoparticle pharmaceutical products, including lipid- and polymer-based formulations. With its modular design and customizable features, the DIANT® LiFT empowers you to optimize your production processes and achieve unparalleled efficiency and control.
The DIANT® LiFT, our production-ready manufacturing skid, comes equipped with:
- DIANT® Jet technology for high throughput
- Continuous particle size analysis through Process Analytical Technology (PAT)
- Integrated, inline particle size control and monitoring with InProcess-LSP
- NanoFlowSizer™, SR-DLS
- Automatic particle size control
- Real-time particle monitoring
- Fast response (~6 seconds per measurement)
- Hybrid or integrated system
- Explosion-proof-rated design
- Capacity options from 0.8 LPM to:
- DIANT® LiFT – 2 LPM maximum
- DIANT® LiFT HP – 20 LPM maximum
- 21 CFR-compliant software
- Continuous or batch operation
- Commercial GMP-compliant manufacturing of lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions
- Continuous Processing: Experience the efficiency and scalability of continuous processing, surpassing the limitations of traditional batch methods.
- Inline Capabilities: Benefit from integrated inline dilution, drug loading, and nanoparticle modification for streamlined production.
- Advanced Characterization: Partner with InProcess-LSP’s cutting-edge NanoFlowSizer™ technology to gain real-time, non-invasive insights into particle size and distribution.
- Customization Options: Tailor your DIANT® LiFT system to your specific needs with a range of optional add-ons, including:
- Customized Process Analytical Technology (PAT) integration
- In-line particle size analyzer
- pH monitoring and control
- Conductivity measurement
- Precise temperature control with a water circulator (sold separately)
The DIANT® LiFT is a versatile and scalable commercial lipid nanoparticle production system that seamlessly transitions from benchtop to large-scale manufacturing. It enables the continuous production of high-quality, liquid-injectable nanoparticle pharmaceutical products, including lipid- and polymer-based formulations. With its modular design and customizable features, the DIANT® LiFT empowers you to optimize your production processes and achieve unparalleled efficiency and control.
The DIANT® LiFT, our production-ready manufacturing skid, comes equipped with:
- DIANT® Jet technology for high throughput
- Continuous particle size analysis through Process Analytical Technology (PAT)
- Integrated, inline particle size control and monitoring with InProcess-LSP
- NanoFlowSizer™, SR-DLS
- Automatic particle size control
- Real-time particle monitoring
- Fast response (~6 seconds per measurement)
- Hybrid or integrated system
- Explosion-proof-rated design
- Capacity options from 0.8 LPM to:
- DIANT® LiFT – 2 LPM maximum
- DIANT® LiFT HP – 20 LPM maximum
- 21 CFR-compliant software
- Continuous or batch operation
- Commercial GMP-compliant manufacturing of lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions
- Continuous Processing: Experience the efficiency and scalability of continuous processing, surpassing the limitations of traditional batch methods.
- Inline Capabilities: Benefit from integrated inline dilution, drug loading, and nanoparticle modification for streamlined production.
- Advanced Characterization: Partner with InProcess-LSP’s cutting-edge NanoFlowSizer™ technology to gain real-time, non-invasive insights into particle size and distribution.
- Customization Options: Tailor your DIANT® LiFT system to your specific needs with a range of optional add-ons, including:
- Customized Process Analytical Technology (PAT) integration
- In-line particle size analyzer
- pH monitoring and control
- Conductivity measurement
- Precise temperature control with a water circulator (sold separately)
DIANT® LiFT : Revolutionize Your Nanoparticle Production
Applications Of DIANT®’s LARU & LiFT
- Lipid nanoparticles – LNP technology has emerged as the leading encapsulation method for complex APIs, including mRNA-based products
- Liposomes
- Polymeric Micelles
- Lipid-Polymer Conjugate Systems
- Suspensions
- Emulsions
Ready To Elevate Your Nanoparticle Production?
Contact Us To Learn More About DIANT's LiFT & LARU
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